Researchers from Cornell University published an article in the January 2014 issue of the American Journal of Preventive Medicine showing that prolonged sitting increases the risk for all cause mortality even if you exercise daily! They studied 93,000 postmenopausal women and found that those who were sedentary for 11 or more hours a day as compared to those sitting less than 4 hours a day had an increased all cause mortality of 12% and an increase in cardiovascular disease of 13%, in coronary heart disease of 27%, and of cancer of 21%!
A sedentary lifestyle is an independent risk factor for premature death even in the face of regular exercise.