Chronic use of antibiotics may help with chronic urinary tract infections, but they also effect the microflora in the GI tract. E. Coli cause 80% of all urinary tract infections. When E. Coli sticks to the lining of the urinary tract it causes inflammation of the urinary tissues. A simple sugar that the body cannot metabolize coats E. Coli and prevents them from sticking to the lining of the bladder or urethra. Cranberry is a rich source of d-mannose.