Recent studies document that depletion of vaginal lactobacilli is associated with recurrent urinary tract infections. It was also shown that replenishing these bacteria via vaginal suppositories halved the recurrence rate for infection. We should be turning to the use of vaginal suppositories to treat women with recurrent urinary tract infections rather than relying on long term antibiotic therapy because this approach worsens the imbalance of the microflora (dysbiosis) in both the vagina and the intestinal tract. The use of d-mannose and vitamin C is also discussed as a treatment for urinary tract infections.