Big pharma is promoting that the use statins far more safe and our MDs have been trained to believe this. There are two types of statins, fat soluble such as Mevacor, Zocor, Lipitor and Lescol and water soluble, such as Pravachol and Crestor. The fat soluble statins must be detoxified in the liver before they become active. Using them with other drugs that need the same liver detox pathways in the liver can greatly extend serious side effects.