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NSAIDs have now been linked to an increased incidence of atrial fibrillation and flutter. The association was strongest for new users. The risk is increased by 40% for COX-1 inhibitors and 70% for COX-2 inhibitors such as Celebrex. This translates to 1 in 250 taking COX-1 drugs and 1 in 140 taking Celebrex. The risk is highest for the elderly, those with rheumatoid...

  Glucocorticoids such as Prednisone and Prednisolone can cause osteoporosis within 3-6 months of use and lead to fractures, especially vertebral fractures. Nearly 5% of women in the US are on these drugs for a variety of conditions such as rheumatoid arthritis, asthma, inflammatory bowel disease, vasculitis, and a myriad of skin disorders. The risk...