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According to the October 2014 issue of the journal, Nature, artificial sweeteners such as saccharine, Splenda, and Nutrasweet (aspartame) cause changes in the human microbiome (intestinal microflora) that lead to glucose intolerance (insulin resistance) within one week in more than half of the subjects of a small study. When stool from these people was tranplanted...

A synthetic "poop" was developed by researchers at the University of Guelph in Canada that works to treat C. diff infections of the GI tract. Now that stool transplants are becoming commonplace in the treatment of C. diff infection, an artificial culture of normal flora of the GI tract has been developed that avoids potential problems of occult infections...